Listing of Clinical Trials

The RLS Foundation does not conduct clinical trials, however as a service to our members we list clinical trial opportunities on our website and in our quarterly newsletter, NightWalkers.  If you would like to include a study in our listing, please email  Listings are free; however, studies must have Institutional Review Board (IRB) approval to be listed.  View currently available clinical trials below.

A clinical trial is a research study that uses volunteers to investigate specific health questions.  Carefully conducted clinical trials are the fastest and safest way to find treatments that work in people.  People who volunteer to participate in clinical trials can play a more active role in their own healthcare, gain access to new research treatments before they are widely available, and help others by contributing to medical research.

The RLS Foundation partners with the Center for Information and Study on Clinical Research Participation (CISCRP) to provide access to RLS clinical trial information through and CenterWatch

Would you or one of your friends or family members (not a blood relative) like to make a lasting contribution to groundbreaking research? A Johns Hopkins team is recruiting adult volunteers for a study on the role of glutamate in WED/RLS. Both healthy volunteers and people who have WED/RLS are needed. In some cases, reimbursement may be available for time and travel expenses. To learn more, contact Sherry Nickerson at 410-550-1046 or

Posted April 2014 


If you live in the New York City area, you may be eligible to participate in a new research opportunity.

We are conducting a research study to determine whether there are changes in the retinal structure of the eyes of individuals with Willis-Ekbom Disease (WED/RLS) compared to individuals with Parkinson’s disease, multiple system atrophy, and healthy controls.

The study will take place at the New York University Langone Medical Center and will require one visit, lasting approximately 1-2 hours.  The visit will include an initial screening and an eye exam.  You will be asked to sit comfortably and to place your chin in a chin rest and to look into a machine that will take pictures of your optic nerve.  The eye examination will take approximately 15 minutes and you will not feel anything while the machine takes pictures of your retina (the back of your eye).

There is no direct benefit to you or expense reimbursement available from your participation in the study. It is hoped that the knowledge gained will be of benefit to others in the future.  Studies done for this research study are not a part of your regular medical care and will not be included in your medical record.

If interested, please contact Dr. Jose Martinez at

Posted January 2013

 NeuroTrials Research in Atlanta, Georgia is conducting a local study to examine the safety and efficacy of a new investigational drug for Willis-Ekbom Disease (WED/RLS). Study-related care and study drug are provided at no cost. Qualified participants will be compensated for time and travel. To qualify, participants must:

  • be 18 -70 years of age
  • have a diagnosis of WED/RLS for over 6 months.
  • experience symptoms of WED/RLS for at least 15 nights per month. 
  • otherwise be in good general health.

If you are interested in learning more about this study, or to find out if you qualify call (404) 851-9934 or visit

Posted April 2012